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Active pharmaceutical ingredient plant, Midwest, Manufacturing case study

Case study · Manufacturing

API maker saves $10M+ a year after losing its largest customer

When its largest customer left the market, a maker of active pharmaceutical ingredients saw EBITDA drop sharply. USC, back more than a decade after a first project, cut batch times, maintenance costs and sourcing costs.

Results

$10M+

in annualized operating savings

Savings are annualized.

The situation

The company had grown through acquisitions and large, high-margin customers. When its largest customer left the market, EBITDA fell steeply.

What the assessment found

  • Lab and production operations built for large jobs that no longer existed
  • High batch and cycle times depressing yield
  • Maintenance outsourced and raw materials bought without regard to cost
  • Slow lab sample approvals holding up production

How the work was done

Batches: cut cycle times

Mapped each batch cycle step with engineering and lab teams, focused on critical-to-quality steps, and gave operators real-time visual targets.

Maintenance: bring it in-house

Rebuilt the maintenance planner role and trained in-house technicians to take over work from outside technicians, using the existing computerized maintenance management system.

Sourcing: buy for total cost

Set up a strategic sourcing plan weighing price, availability and vendor location for global raw materials.

Lab: speed up approvals

Added capacity planning and scheduling tools in quality control and quality assurance to cut lab-to-production times.

Lasting impact

The company reset its operations for a smaller customer base, with in-house maintenance, cost-based sourcing and faster lab approvals, and cut more than $10 million a year in cost.

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